Daniel Trotta, Reuters

Major League Baseball is asking the U.S. government for special permission to sign players in Cuba, handing the administration of U.S. President Barack Obama the opportunity to try some baseball diplomacy while dealing a setback to human traffickers.

The U.S. trade embargo generally bars MLB from any agreement directing money to the Cuban government, but the White House says baseball is one area where it can advance U.S. goals and the Treasury Department's Office of Foreign Assets Control (OFAC) has authority to allow a deal.

MLB and Cuba are closer than at any time since the 1959 revolution, as evidenced by a goodwill tour last week in which big leaguers, including Cuban defectors, gave clinics to Cuban youth...